Anti-HLA-E (Human) mAb (Clone: 4D12)

MBL

Catalog No.:
MBL-K0215-3
Anti-HLA-E (Human) mAb (Clone: 4D12)
Anti-HLA-E (Human) mAb (Clone: 4D12)
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HLA-E (human leucocyte antigen-E) is a conserved class I major histocompatibility molecule. It binds to the leader peptide derived from the polymorphic classical MHC molecules HLA-A, HLA-B and HLA-C. This peptide binding stabilizes the HLA-E protein and allows it to migrate to the cell surface. HLA-E then interacts with CD94/NKG2A receptors on natural killer cells. This interaction inhibits natural killer cell-mediated lysis of cells displaying HLA-E. In virally infected or tumor cells, down-regulation of HLA-A, HLA-B and HLA-C production prevents stabilization of HLA-E by the leader peptide. Under these circumstances, HLA-E is degraded before it reaches the cell surface and the cell is then vulnerable to lysis by natural killer cells. Monoclonal Antibody of 100 μl targeting HLA-E for FCM, IHC.

Product Specifications
Application FC, IHC
Reactivity Human
Clonality Monoclonal IgG1
Host Mouse
Immunogen Antibody obtained by immunizing HLA-B27 transgenic mice to HLA-E protein
Formulation 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
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